A new PCR technology that’s unbelievably real.

Countable PCR delivers true single-molecule quantitation from a straightforward workflow. With 30 million compartments, it’s PCR like you’ve never experienced before.

Single molecule isolation changes everything for PCR.

True quantitation
Count molecules directly without Poisson correction, achieving truly accurate quantitation.
Unmatched precision
Reach precision levels 10X better than digital PCR, with CVs consistently below 1%.
Highest sensitivity
Identify mutations as low as 0.004% MAF – perfect for oncology and other rare event assays.
Clean fluorescent signal
Separate fluorophores cleanly with laser-based detection, avoiding bleedthrough.
Effortless multiplexing
Rapidly develop multiplex assays without PCR bias, saving you valuable time and resources.
Broad dynamic range
Easily count up to 1 million molecules, capturing all your data without compromise.

Results ready when you are.

Analysis is the hidden bottleneck in most PCR workflows. Drawing manual thresholds, gating scatter plots, double-checking replicates — it's slow, subjective, and error-prone. Countable PCR doesn't require any of that.

Single molecule isolation without microfluidics

Every Countable PCR reaction begins with 30 million picoliter-sized compartments, forming a gel-like matrix inside a PCR tube with a simple centrifugation step. This massive partitioning reliably isolates up to 1 million target molecules, allowing each molecule to be amplified separately for precise and highly accurate results.

Unbiased amplification

Each molecule is amplified in isolation, eliminating cross-talk, PCR bias, and signal interference. The result — cleaner data and dramatically easier assay development than legacy PCR platforms. And it’s all done in a standard thermal cycler, no special hardware required.

Counting in 3D

The Countable system uses laser-based lightsheets to clearly distinguish each fluorophore, giving you crisp, high-resolution multiplex signals.  It rapidly scans your entire reaction – directly in the PCR tube – in less than a minute.  No bleedthrough, no sample loss, just clear and reliable results every time.

With ~30M compartments, we’re seeing significantly higher sensitivity with fewer reactions in our oncology assays and new opportunities have opened up in the fields of NIPT and infectious disease.

Tricia Zwiefelhofer
Director of R&D, LabCorp
Countable PCR Early Access Customer
1+ year

Reimagine what PCR will do for you.

By isolating and amplifying single molecules without bias, Countable PCR unlocks a new class of assays that go beyond what qPCR or dPCR support.

Detect rare events
Quantitate DNA linkage
Count long amplicons
Preserve DNA for downstream analysis
Multiplex quickly

Get high-sensitivity, high-precision counting for all your gene targets.

Contact a specialist