Go beyond the limits of digital PCR.
Countable PCR delivers direct, precise, and sensitive detection when it matters most. Count on certainty.
A new class of measurement.
Unambiguous detection at the level of the individual molecule unlocks measurements that were impossible or impractical with PCR, dPCR, or NGS.
Single-molecule linkage
Resolve true linkage states of individual molecules, with absolute clarity
Simplified multiplexing
Eliminate PCR bias and reduce the need for extensive assay optimization
Broad dynamic range
Simultaneously generate true counts of rare and abundant targets in a single assay
High precision & reproducibility
Measure minute fold changes in expression or copy number
Simply count everything.
A brief introduction to the simplicity and power of Countable PCR.
30M
compartments
100%
of sample analyzed
<1%
CV across runs
See Countable PCR run on your samples — typical turnaround in days.
Where precision counts
Cell & gene therapy
Genome integrity, titer, and VCN — from ITR to ITR in a single run.
Oncology & liquid biopsy
Rare variants at 0.004% VAF in a high wild-type background.
Molecular diagnostics
Absolute quantification you can standardize across sites.
Viral genome integrity
Distinguish complete genomes from partials with linkage.
Genome editing QC
Quantify edits and unintended events with single-molecule clarity.
Fusion detection
Resolve fusion transcripts directly, no sequencing required.
How the platforms compare.
Quantification, range, precision, and sensitivity — side by side.
Quantitative PCR
qPCR
Digital PCR
dPCR
Single-molecule counting PCR
Quantification method
Real-time detection based on amplification kinetics
Relative to reference or standard curve
End-point detection based on binary signal
“Absolute” signal with Poisson correction for multiple molecules per partition
End-point detection based on binary signal
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Direct single-molecule counting
Dynamic range
10⁶ — 10⁷ range
Theoretically broad, contingent on linear amplification
10⁴—10⁵ range
Narrow range, better precision
10⁶ range
Broadest, highest precision
Precision
Low
50-100% CV
Moderate
-10% CV
High
<1% CV
Sensitivity
Limited
>1% VAF
High, with effort
~0.03% VAF
Highest
0.004% VAF
Quantitative PCR
qPCR
Quantification method
Real-time detection based on amplification kinetics
Relative to reference or standard curve
Dynamic range
10⁶ — 10⁷ range
Theoretically broad, contingent on linear amplification
Precision
Low
50-100% CV
Sensitivity
Limited
>1% VAF
Digital PCR
dPCR
Quantification method
End-point detection based on binary signal
“Absolute” signal with Poisson correction for multiple molecules per partition
Dynamic range
10⁴—10⁵ range
Narrow range, better precision
Precision
Moderate
-10% CV
Sensitivity
High, with effort
~0.03% VAF
Single-molecule counting PCR
Quantification method
End-point detection based on binary signal
Direct single-molecule counting
Dynamic range
10⁶ range
Broadest, highest precision
Precision
High
<1% CV
Sensitivity
Highest
0.004% VAF
One platform. Endless flexibility.
Countable PCR Core Bundle
A familiar PCR workflow with single-molecule counting: superior precision, reproducibility, sensitivity, and linear performance across a wide dynamic range.
≥10x
More sensitive than digital PCR.
6-log
Linear at R²=0.9999.
RNA Module
One-step RT + amplification for accurate RNA counts.
Assay Services
Proof-of-concept studies, sample to data.
Countable 4
Up to 4 targets, 96 samples per run, automated analysis and QC.
Control Software
21 CFR Part 11–ready instrument control, audit trails, signed reports.
Get a closer look at Countable PCR.
"Using a 4-color optical setup, we demonstrate that we can incorporate 10 different fluorescent dyes in the same [reaction]"
Janice H. Lai, et al. 2023.
We're now Countable Labs but some publications use our former name Enumerix. Also, our technology is Countable PCR, formerly UltraPCR.
"Single template separation ... can aid high-order multiplexing assay designs to achieve NGS-like precision DNA counting"
Eleen Y. Shum, et al. 2022
We're now Countable Labs but some publications use our former name Enumerix. Also, our technology is Countable PCR, formerly UltraPCR.
“This approach exhibits improved accuracy over existing dPCR platforms and enables a greatly increased dynamic range…”
Peiyu Liao, et al. 2020
We're now Countable Labs but some publications use our former name Enumerix. Also, our technology is Countable PCR, formerly UltraPCR.
Count anything.
See what becomes measurable when counting is precise and effortless.
